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In vivo studies – lesions. (A) A 10 mg/kg dose of indomethacin produced punctate hemorrhagic spots and small punch-out lesions on the small intestine in rats. (B) Small intestinal lesion scores. Omeprazole and lansoprazole pretreatment did not alter the indomethacin-induced mucosal lesion score, while revaprazan pretreatment tended to reduce the lesion score (p=0.06). Indo-PC showed significantly fewer gross small intestine mucosal lesions than Indomethacin alone (p<0.05)*.
