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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Anesthesiology. 2012 Oct;117(4):822–835. doi: 10.1097/ALN.0b013e31826a4ae3

Figure 5. CD11c+ alveolar macrophages are required for the full pathophysiologic response to ventilated lung I/R injury.

Figure 5

Alveolar macrophages (CD11c+) were depleted by treating transgenic CD11c-DTR mice with diphtheria toxin (DTx) (intraperitoneally at day -1) and these mice (or control mice that received PBS carrier) underwent I/R surgery and lungs were assessed for neutrophil infiltration by histopathology 3 h after reperfusion. Each image is representative of histology images from 3 independent surgeries.

I/R: ischemia-reperfusion; PBS: phosphate buffered saline; IP: intraperitoneal; DTx: diphtheria toxin.