Table 3.

Sites of first disease-free survival (DFS) event according to histologic type and cohort

	All patients (full cohort)		Patients with estrogen receptor- and grade 3 tumors (restricted cohort)
	Medullary	Ductal	Medullary	Ductal
Total patients	127	8096	47	1407
No DFS event	58 (46)	3577 (44)	26 (55)	642 (46)
Breast cancer-related DFS events	44 (35)	3770 (47)	14 (30)	674 (48)
Local	6 (5)	666 (8)	0	94 (7)
Contralateral breast	7 (6)	333 (4)	4 (9)	44 (3)
Regional	8 (6)	493 (6)	5 (11)	116 (6)
Distant (as first site)	23 (18)	2278 (28)	5 (11)	420 (30)
Distant soft tissue	4 (3)	129 (2)	0	33 (2)
Bone	6 (5)	880 (11)	1 (2)	105 (7)
Viscera	13 (10)	1269 (16)	4 (9)	282 (20)
Non-breast cancer-related events	25 (9)	749 (29)	7 (6)	91 (15)
Second primary non-breast	12 (9)	362 (4)	3 (6)	49 (3)
Death without prior cancer event	11 (9)	360 (4)	3 (6)	39 (3)
Unknown	2 (2)	27 (0.3)	1 (2)	3 (0.2)