Figure 4.
11C-Acetoacetate uptake into the brain of rats on a control diet (normal), ketogenic diet, or fasted 48 h (means ± SD; n = 4/group), expressed as metabolic rate for acetoacetate. The uptake was measured by PET imaging and shows that brain uptake of ketones is stimulated to an approximately equivalent extent by 48 h fasting or 10 d on a very high fat ketogenic diet [154].