TABLE 2.
PET studies showing no difference (A) or lower (B) cerebral metabolic rate for glucose (CMRg) in the elderly with no known cognitive impairment.
| Reference | n in each group with age (y) | Atrophy correction | CMRg (mg/100 g/min) |
|---|---|---|---|
| A: NO DIFFERENCE WITH AGE | |||
| Duara et al (1983)217 | n = 21 men, 21–83 y | No | 4.3 |
| De Leon et al (1984)218 | n = 15, 26 y n = 22, 67 y |
No | 3.8 |
| Duara et al (1984)219 | n = 40 men, 21–83 y | No | 4.6 |
| Horowitz et al (1986)220 | n = 15 men, 20–32 y n = 15 men, 64–83 y |
No | 4.9 |
| Schlageter et al (1987)69 | n = 49 men, 21–83 y | Yes | 5.6 |
| Ibanez et al (2004)68 | n = 11 men, 22–24 y n = 13 men, 55–82 y |
Yes | 9.5 |
| Yanese et al (2005)221 | n = 71 men, 68 women, 24–81 y | Yes | SUV values; CMRg not given |
| Kochunov et al (2009)222 | n = 19 adults, 59–92 y | Yes | SUV values; CMRg not given |
| B: LOWER IN ELDERLY | |||
| Kety (1956)a, 223 | n = 16, 10–92 y | No | 50% ↓ >70 y, versus 10–20 y old |
| Dastur et al (1963)224 | n = 15 young men n = 26 elderlyb men |
No | young = 6.0, elderly = 4.6 (23% ↓ in elderly) |
| Kuhl et al (1982)163 | n = 40, 20–74 y old | No | young = 5.1, elderly = 3.9 (24% ↓ in elderly) |
| De Santi et al (1995)225 | n = 40, 28 y n = 31, 68 y |
No | 12–24% ↓ in frontal & temporal lobes for elderly |
| Loessner et al (1995)226 | n = 64 men, 56 women, 19–79 y | No | ↓ in frontal lobes for elderly over 6th decade |
| Moeller et al (1996)227 | n = 62 men, 68 women, 21–90 y <50 y = young >50 y = elderly |
No | 13% ↓ from 20 to 80 y; ↓ in medial frontal and frontal operculum |
| Petit-Taboué et al (1998)205 | n = 24, 20–67 y | No | 6% ↓ per decade in several cortical regions and anterior thalamus |
| Bentourkia et al (2000)228 | n = 10, 26 y n = 10, 65 y |
Yesc | young = 7.3, elderly = 6.3 (13% ↓ for elderly) |
| Willis et al (2002)191 | n = 38 men, 28 women, 20–69 y | No | young = 8.1, elderly = 6.9 (14% ↓ in elderly); ↓ in cingulate, frontal, temporal cortices from 20 to 60 y old |
| Kalpouzos et al (2009)204 | n = 21 men, 24 women, 20–83 y | Yes | ↓ in frontal cortex for elderly |
a
N2O method provided cerebral metabolic rate of oxygen (CMRO2)
b
inadequate information about criteria for state of health in elderly
c
no cerebral atrophy detected using MRI