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. 2010 Aug 25;30(34):11388–11397. doi: 10.1523/JNEUROSCI.1356-10.2010

Figure 6.

Figure 6.

The processing of PMP22 in myelinating SCs. A, Total protein lysates of DRG explants from Wt and C22 mice after treatment with Ct or RM were incubated with endo-H (H) or PNGase F (N) and PMP22 was detected by Western blots. Endo-H-resistant (R) (square bracket, ∼22 kDa) and endo-H-sensitive (S) (∼18 kDa) fractions of PMP22 are marked. Control (C) protein lysates for each sample without enzymatic treatment are also shown. B, Semiquantitative analyses of data from three independent experiments for endo-H-resistant (p = 0.0576, p = 0.0855, **p < 0.01, ***p < 0.001, t test, mean ± SD) and endo-H-sensitive fractions (##p < 0.01, ##p < 0.001, t test, mean ± SD) are shown.