Table 1.
Immune responses to replacement lysosomal enzymes
| Disease | Product | Enzyme | Product status | Patients with IgG antibody (%) | Reference |
|---|---|---|---|---|---|
| Gaucher’s | Ceredase | Alglucerase | Licensed | 12.8 | 18 |
| Cerezyme | Imiglucerase | Licensed | 13.8 | Product label | |
| Fabry’s | Fabrazyme | Agalsidase beta | Licensed | 90 | 20 |
| Hurler’s (MPS I) | Aldurazyme | α-L-iduronidase | Licensed | 91 | 55 |
| Pompe’s | Myozyme | Acid-α-glucosidase | Licensed | 89 | Product label |
| Hunter’s (MPS II) | Elaprase | Iduronate-2-sulfatase | Licensed | 51 | Product label |
| Maroteaux-Lamy (MPS VI) | Naglazyme arylsulfatase B | N-acetylgalactosamine-4- sulfatase | Phase 3 completed | 97 | 87 |
MPS, mucopolysaccharidosis.