Table 2.
Mammary tumor incidence in parous FVB/N mice receiving i.duc PLD
| i.duc/duct | Tumor incidencea |
P value | Tumor type |
|---|---|---|---|
| PLD 40 µg | 6/9 | 0.009 | carcinoma, carcinosarcoma |
| PLD 20 µg | 3/7 | 0.077 | carcinoma |
| PLD 10 µg | 3/9 | 0.206 | carcinoma, sarcoma, b LN tumor |
| Vehicle (50 µl) | 0/7 | >0.999 | |
| No treatment | 0/8 | Reference |
a
The mice were observed for 42 weeks
b
One case of microscopic epithelial tumor in the lymph node (LN) without visible or additional microscopic lesions in the mammary gland sections examined
An exact logistic regression analysis showed there was no change in tumor incidence with a change in PLD dosage (P = 0.449)