Skip to main content
. Author manuscript; available in PMC: 2012 Oct 22.
Published in final edited form as: Ann N Y Acad Sci. 2008;1132:104–113. doi: 10.1196/annals.1405.039

FIGURE 8.

FIGURE 8

siRNA D6 silences the functional activity of αC418W-AChR. Histograms show distribution of the open probability (Popen) of clusters of AChR channel openings in the presence of 10 μM ACh. Each cluster represents the activity of one channel. (A) Wild-type AChR. (B) αC418W-AChR. (C) Wild-type AChR coexpressed with αC418W-AChR. (D) Wild-type AChR coexpressed with αC418W-AChR in presence of siRNA D6. Note disappearance of nearly all high-probability channel openings typical of αC418W-AChR. (Reproduced by permission from Ref. 20.)