Table 4.
Brain regions containing MS-related lesions.
| Brain Region | No. with Lesions | Median (Range) Lesions | Mean (SD) Lesions | Median (Range) Lesion Volumes (mm3) | Mean (SD) Lesion Volume (mm3) | Median (Range) Region Volume (mm3) | Mean (SD) Region Volume (mm3) | % Volume& No. Lesions/Mean Region Volume |
|---|---|---|---|---|---|---|---|---|
| Cerebral Cortex Left | 63 | 26 (6–119) | 32.52 (22.75) | 5102.47 (748.89–18726.05) | 6537.50 (5283.93) | 364954.16 (285698.56–525370.75) | 372977.06 (47800.37) | 1.75 & .00 |
| Cerebral Cortex Right | 63 | 27 (6–97) | 31.64 (20.25) | 448.88 (19.94–18757.07) | 6396.37 (5106.45) | 374941.94 (289699.88–521832.44) | 380037.92 (47377.99) | 1.68 & .00 |
| Medial Frontal Lobe Left | 63 | 12 (2–74) | 14.44 (10.59) | 1167.61 (90.84–6336.55) | 1503.67 (1511.21) | 95958.82 (76663.37–148421.45) | 99267.06 (14813.33) | 1.51 & .01 |
| Medial Frontal Lobe Right | 63 | 13 (1–41) | 13.00 (6.99) | 926.11 (2.22–7222.78) | 1526.88(1623.76) | 100844.17 (77777.80–149932.47) | 103422.50 (15002.34) | 1.48 & .01 |
| Temporal Lobe Left | 63 | 10 (1–37) | 12.86 (8.30) | 704.55 (24.37–6041.88) | 1170.74 (1200.34) | 112783.91 (85505.73–141699.39) | 112548.18 (13785.93) | 1.04 & .01 |
| Temporal Lobe Right | 61 | 12 (0–34) | 15.03 (9.02) | 746.65 (0–5448.10) | 1121.33 (1202.92) | 117857.58 (89059.52–164145.39) | 119117.01 (14855.76) | .94 & .02 |
| Medial Temporal Area Left | 58 | 4 (0–15) | 5.27 (4.29) | 28.80 (0–356.71) | 55.39 (65.70) | 5764.93 (4515.34–7349.07) | 5741.75 (715.49) | .96 & .09 |
| Medial Temporal Area Right | 57 | 6 (0–20) | 6.94 (5.22) | 44.31 (0–352.28) | 80.82 (86.00) | 6214.69 (4630.55–9048.41) | 6381.95 (875.38) | 1.27 & .11 |
| Superior Frontal Lobe Left | 60 | 5 (0–25) | 6.16 (4.97) | 197.19 (0–4076.66) | 525.02 (832.79) | 68826.88 (55050.42–93497.31) | 70159.46 (8843.42) | .75 & .00 |
| Superior Frontal Lobe Right | 54 | 4 (0–28) | 4.71 (5.01) | 170.60 (0–3296.78) | 401.37 (621.85) | 65288.60 (50896.22–88217.59) | 66075.80 (8208.68) | .61 & .01 |
| Hippocampus Left | 48 | 3 (1–13) | 3.42 (3.20) | 15.51 (0–314.61) | 40.27 (56.35) | 2767.26 (1632.88–3717.74) | 2715.59 (399.95) | 1.48 & .13 |
| Hippocampus Right | 47 | 3 (0–11) | 3.44 (3.24) | 17.73 (0–288.03) | 37.14 (53.42) | 2222.22 (1440.12–3013.18) | 2207.70 (343.99) | 1.68 & .16 |
| Inferior Frontal Lobe Left | 46 | 2 (0–25) | 3.87 (5.11) | 28.80 (0–908.39) | 88.73 (159.65) | 24639.42 (18947.61–33630.23) | 25081.41 (3414.52) | .35 & .02 |
| Inferior Frontal Lobe Right | 48 | 1 (0–20) | 5.16 (5.37) | 17.73 (0–762.16) | 78.00 (143.33) | 26216.91 (20988.15–36492.76) | 26880.43 (3627.71) | .29 & .02 |
| Insular White Matter Left | 39 | 1 (0–19) | 2.02 (3.50) | 4.43 (0–194.97) | 17.58 (35.81) | 2038.33 (1328.48–2818.21) | 2030.24 (335.06) | .87 & .10 |
| Insular White Matter Right | 42 | 1 (0–11) | 2.09 (2.60) | 4.43 (0–139.58) | 16.18 (26.16) | 1741.44 (1304.97–2895.76) | 1799.54 (330.77) | .90 & .12 |
| Insular Gray Matter Left | 36 | 1 (0–17) | 1.95 (3.35) | 2.22 (0–383.30) | 23.32 (66.48) | 4887.56 (3015.40–7151.88) | 5012.94 (330.77) | .46 & .04 |
| Insular Gray Matter Right | 39 | 1 (0–12) | 1.98 (2.64) | 4.43 (0–168.38) | 21.03 (66.48) | 5574.39 (3949.16–8000.45) | 5576.32 (883.16) | .38 & .04 |
| Anterior Cingulate Gyrus Left | 37 | 1 (0–11) | 1.25 (1.81) | 2.21 (0–141.80) | 11.64 (22.99) | 6150.44 (4590.67–8875.60) | 6286.86 (1036.49) | .19 & .02 |
| Anterior Cingulate Gyrus Right | 36 | 1 (1–10) | 1.51 (1.98) | 4.43(0–602.64) | 25.36 (81.84) | 8040.33 (6172.60–13734.36) | 8181.42 (1448.92) | .31& .02 |
| Orbitofrontal Cortex Left | 38 | 1 (0–9) | 1.79 (2.03) | 6.65 (0–190.54) | 27.33 (45.65) | 11000.34 (8197.63–16009.75) | 11378.36 (1740.91) | .24 & .02 |
| Orbitofrontal Cortex Right | 36 | 1 (0–10) | 1.83 (2.55) | 2.22 (0–248.15) | 23.77 (47.58) | 10523.99 (7585.83–14119.87) | 10567.77 (1515.99) | .22 & .02 |
| Thalamus Left | 30 | 0 (0–9) | 1.40 (2.15) | 0 (0–268.09) | 16.28 (39.78) | 6314.39 (4211.81–9103.80) | 6358.35 (959.02) | .26 & .02 |
| Thalamus Right | 32 | 1 (0–13) | 1.48 (2.30) | 2.22 (0–303.53) | 13.65 (43.49) | 5691.82 (3298.99–7479.79) | 5743.72 (844.77) | .24 & .03 |
| Parietal Operculum Left | 29 | 0 (0–4) | .70 (.94) | 0 (0–146.23) | 12.59 (29.28) | 1761.38 (901.74–2951.15) | 1780.41 (427.23) | .71 & .04 |
| Parietal Operculum Right | 21 | 0 (0–5) | .60 (1.13) | 0 (0–223.77) | 14.03 (37.83) | 1214.14 (613.71–2321.92) | 1251.13 (353.97) | 1.12 & .05 |
| Amygdala Left | 7 | 0 (0–4) | .18 (.55) | 0 (0–24.37) | .74 (3.31) | 514.01 (248.15–837.49) | 517.78 (119.24) | .14 & .03 |
| Amygdala Right | 5 | 0 (0–2) | .13 (.46) | 0 (0–141.80) | .88 (4.41) | 469.70 (241.50–952.70) | 492.31 (145.41) | .18 & .03 |
| Brainstem Left | 5 | 0 (0–1) | .08 (.27) | 0 (0–26.59) | 1.09 (4.71) | 11190.88 (7796.61–14895.32) | 11415.70 (1535.31) | .01 & .00 |
| Brainstem Right | 4 | 0 (0–2) | .08 (.33) | 0 (0–90.84) | 2.74 (14.92) | 10260.33 (7016.73–14042.32) | 10489.84 (1439.51) | .03 & .00 |
| Pons Left | 4 | 0 (0–1) | .06 (.25) | 0 (0–24.37) | 0.53 (3.13) | 6850.56 (4570.73–9438.35) | 6875.53 (1005.03) | .01 & .00 |
| Pons Right | 4 | 0 (0–4) | .11 (.54) | 0 (0–48.74) | 1.13 (6.50) | 6234.63 (4249.48–8826.86) | 6346.82 (924.35) | .02 & .00 |
| Cerebellum Left | 2 | 0 (0–1) | .03 (0–1) | 0 (0–62.04) | 1.09 (7.85) | 56293.36 (47495.31–78384.87) | 57195.03 (599.59) | .00 & .00 |
| Cerebellum Right | 1 | 0 (0–1) | .02 (0–1) | 0 (0–2.22) | .04 (.28) | 59494.87 (43500.62–77206.19) | 59252.67 (6598.92) | .00 &.00 |
| Medial Lemniscus Left | 0 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 571.62 (350.06–839.70) | 577.18 (103.34) | -- |
| Medial Lemniscus Right | 2 | 0 (0–2) | .05 (.28) | 0 (0–6.65) | .18 (1.00) | 562.76 (383.30–786.53) | 567.43 (85.04) | .03 & .00 |
| Superior Colliculus Left | 0 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 307.97 (175.03–509.58) | 314.79 (73.67) | -- |
| Superior Colliculus Right | 1 | 0 (0–1) | .12 (.13) | 0 (0–4.43) | 0.07 (.58) | 316.83 (197.19–595.99) | 335.04 (88.31) | .02 & .04 |
Listing is in order of the number of subjects exhibiting lesions within the given brain regions and the % volume of the brain region involved. Dark gray indicates brain regions most closely associated with hearing. N = 63.