Figure 1.

Distribution of GREMLIN edges between different domains. Mapping of (A) all (B) RT and (C) non RT edges identified by GREMLIN (at λ = 38) mapped onto the bovine rhodopsin structure (PDB ID: 1U19). The edges are EC-EC (red), EC-TM (green), EC-IC (blue), TM-TM (cyan), IC-TM (orange), IC-IC (grey40), EC-RT (red), RT-TM (blue), IC-RT (green) and RT-RT (orange) where EC, IC, TM and RT represent residues in extracellular, intracellular, transmembrane and RT (ligand binding) domains. In (D) The percentage of edges for GREMLIN (squares) and null set (diamonds) are plotted against the common ligand binding pockets sorted by their size. The bars indicate fold enrichment (values on secondary y-axis) of edges in GREMLIN over the null set