Table 5.

Sensitivity analysis of outcome misclassification^*

	Uncorrected	Alker 2007	Hutagalung 2005	Rogers 2009
Sensitivity	25.9	22.6	15.1	15.4
Specificity	88.5	95.0	94.6	95.1
PPV	13.5	27.8	24.2	34.3
NPV	94.6	93.4	90.6	87.0

Abbreviations: PPV positive predictive value, NPV negative predictive value.

^*The uncorrected estimates are from this study. The relationship between day-28 PCR-uncorrected treatment failure and 42-day PCR-corrected treatment failure from three different studies was used to calculate the sensitivity, specificity, PPV, and NPV of day-2 parasitaemia as an indicator of 42-day PCR-corrected treatment failure.