Table 1.
Hazard ratios for disease progression in breast cancer patients
| All (N = 980) | Events (N = 141) | Model 1a | Model 2b | |
|---|---|---|---|---|
| Age (mean(SD)) |
48 (9.8) |
49 (11.7) |
1.02 (1.00-1.04) |
1.01 (0.99-1.03) |
| ≤39 |
191 (19.5) |
30 (21.3) |
1.00 |
1.00 |
| 40-49 |
422 (43.0) |
50 (35.5) |
0.86 (0.54-1.36) |
0.76 (0.48-1.22) |
| 50-59 |
241 (24.6) |
34 (24.1) |
1.02 (0.62-1.70) |
0.83 (0.48-1.42) |
| ≥60 |
126 (12.9) |
27 (19.1) |
1.66 (0.97-2.82) |
1.21 (0.67-2.18) |
| Menopausal status |
|
|
|
|
| Pre |
610 (63.0) |
74 (53.6) |
1.00 |
1.00 |
| Post |
359 (37.0) |
64 (46.4) |
1.50 (0.93-2.42) |
1.38 (0.85-2.25) |
| BMI, kg/m2 (mean(SD)) |
23 (2.9) |
23 (3.2) |
0.98 (0.92-1.04) |
0.97 (0.91-1.03) |
| <25 |
753 (77.6) |
107 (77.0) |
1.00 |
1.00 |
| ≥25 |
217 (22.4) |
32 (23.0) |
0.85 (0.56-1.28) |
0.79 (0.52-1.20) |
| Education |
|
|
|
|
| Middle school |
224 (22.9) |
46 (32.6) |
1.00 |
1.00 |
| High school |
402 (41.2) |
56 (39.7) |
0.68 (0.45-1.05) |
0.69 (0.45-1.05) |
| College |
351 (35.9) |
39 (27.7) |
0.58 (0.36-0.94) |
0.58 (0.36-0.93) |
| Alcohol drinking |
|
|
|
|
| <1/month |
559 (57.5) |
85 (60.7) |
1.00 |
1.00 |
| 1-3/month |
354 (36.4) |
46 (32.9) |
0.83 (0.57-1.21) |
0.83 (0.57-1.22) |
| 1+/week |
59 (6.1) |
9 (6.4) |
1.12 (0.56-2.25) |
1.09 (0.54-2.19) |
| Recruited sites |
|
|
|
|
| SNU |
511 (52.1) |
73 (51.8) |
1.00 |
1.00 |
| AMC |
469 (47.9) |
68 (48.2) |
0.92 (0.65-1.30) |
0.89 (0.63-1.26) |
| TNM stage |
|
|
|
|
| I |
400 (40.8) |
25 (17.7) |
1.00 |
1.00 |
| II |
416 (42.5) |
72 (51.1) |
2.78 (1.74-4.44) |
2.71 (1.69-4.35) |
| III |
164 (16.7) |
44 (31.2) |
4.27 (2.57-7.11) |
4.17 (2.50-6.96) |
| Tumor size |
|
|
|
|
| <2 cm |
526 (54.9) |
42 (29.8) |
1.00 |
1.00 |
| ≥2 cm |
431 (44.9) |
99 (70.2) |
2.57 (1.74-3.79) |
2.51 (1.70-3.72) |
| Tx |
2 (0.2) |
|
|
|
| Lymph node status |
|
|
|
|
| Negative |
577 (58.9) |
60 (42.6) |
1.00 |
1.00 |
| Positive |
390 (39.8) |
78 (55.3) |
1.47 (1.03-2.11) |
1.46 (1.02-2.09) |
| Nx |
13 (1.3) |
3 (2.1) |
|
|
| Hormone status |
|
|
|
|
| ER + and/or PR+ |
698 (72.6) |
74 (53.6) |
1.00 |
1.00 |
| ER–/PR– |
264 (27.4) |
64 (46.4) |
2.06 (1.41-3.01) |
2.06 (1.40-3.02) |
| Nuclear grade |
|
|
|
|
| I-II |
525 (55.2) |
57 (41.0) |
1.00 |
1.00 |
| III | 426 (44.8) | 82 (59.0) | 1.15 (0.78-1.69) | 1.12 (0.75-1.65) |
Abbreviation: AMC, Asan Medical Center; ER, estrogen receptor; PR, progesterone receptor; SNU, Seoul National University.
Data are presented as frequency (percentage), except for age and BMI in continuous variable, which are expressed as mean (SD).
a Adjusted for age, TNM stage and hormone status and nuclear grade.
b Adjusted for age, education, recruited site, TNM stage, hormone status and nuclear grade.