Table 2.
Association between one-carbon metabolism related nutrients intake and disease progression in breast cancer patients
| All (N = 980) | Events (N = 141) | Model 1a | Model 2b | |
|---|---|---|---|---|
| Vitamin B2 intake, mg |
|
|
|
|
| Continuous (mean(SD)) |
1.0 (0.4) |
1.0 (0.4) |
1.21 (0.67-2.18) |
1.29 (0.71-2.33) |
| 1st quartile (0.1-0.6) |
192 (19.6) |
29 (20.6) |
1.00 |
1.00 |
| 2nd quartile (0.7-0.8) |
226 (23.1) |
26 (18.4) |
0.94 (0.54-1.61) |
0.99 (0.58-1.73) |
| 3rd quartile (0.9-1.1) |
295 (30.1) |
44 (31.2) |
1.20 (0.71-2.02) |
1.28 (0.75-2.18) |
| 4th quartile (1.2-3.4) |
267 (27.2) |
42 (29.8) |
1.40 (0.76-2.61) |
1.58 (0.84-2.98) |
| Ptrend |
|
|
0.21 |
0.12 |
| Vitamin B6 intake, mg |
|
|
|
|
| Continuous (mean(SD)) |
1.5 (0.5) |
1.5 (0.6) |
1.41 (0.90-2.20) |
1.38 (0.88-2.17) |
| 1st quartile (0.1-1.0) |
174 (17.8) |
26 (18.4) |
1.00 |
1.00 |
| 2nd quartile (1.1-1.3) |
262 (26.7) |
39 (27.7) |
1.27 (0.75-2.16) |
1.28 (0.75-2.18) |
| 3rd quartile (1.4-1.7) |
238 (24.3) |
27 (19.2) |
0.97 (0.72-1.80) |
0.98 (0.53-1.83) |
| 4th quartile (1.8-4.8) |
306 (31.2) |
49 (34.8) |
1.61 (0.82-3.16) |
1.65 (0.84-3.24) |
| Ptrend |
|
|
0.29 |
0.27 |
| Folate intake, mg |
|
|
|
|
| Continuous (mean(SD)) |
213.8 (99.3) |
212.9 (98.3) |
1.00 (0.99-1.00) |
1.00 (0.99-1.00) |
| 1st quartile (9–147) |
240 (24.5) |
37 (26.2) |
1.00 |
1.00 |
| 2nd quartile (148–199) |
248 (25.3) |
32 (22.7) |
0.82 (0.51-1.33) |
0.82 (0.51-1.34) |
| 3rd quartile (200–256) |
247 (25.2) |
33 (23.4) |
0.96 (0.58-1.60) |
0.97 (0.58-1.63) |
| 4th quartile (257–970) |
245 (25.0) |
39 (27.7) |
1.18 (0.68-2.03) |
1.20 (0.69-2.07) |
| Ptrend |
|
|
0.50 |
0.46 |
| Combined score |
|
|
|
|
| Low (0) |
302 (30.8) |
44 (31.2) |
1.00 |
1.00 |
| Medium (1–2) |
289 (29.5) |
35 (24.8) |
0.92 (0.58-1.47) |
0.93 (0.58-1.50) |
| High (3) |
389 (39.7) |
62 (44.0) |
1.40 (0.84-2.33) |
1.46 (0.87-2.43) |
| Ptrend | 0.20 | 0.15 |
Data are presented as frequency (percentage), except for continuous variable, which are expressed as mean (SD).
a Adjusted for age, TNM stage, hormone status, nuclear grade and total calorie.
b Adjusted for age, education, recruited site, TNM stage, hormone status, nuclear grade and total calorie.