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. 2012 Aug 28;11:59. doi: 10.1186/1475-2891-11-59

Table 3.

Association between median of one-carbon metabolism related nutrients and disease progression in breast cancer patients stratified by clinicopathological characteristics

 
  
 Below median
 Above median
  
    No. of total No. of events No. of total No. of events HR (95%CI)a
 
 TNM stage
  
  
  
  
  
Vitamin B2, mg
 I-II
 350
 39
 466
 58
 1.40 (0.85-2.30)
 
 III
 68
 16
 96
 28
 1.13 (0.52-2.43)
Vitamin B6, mg
 I-II
 362
 46
 454
 51
 1.02 (0.61-1.73)
 
 III
 74
 19
 90
 25
 1.05 (0.49-2.27)
Folate, mg
 I-II
 397
 48
 419
 49
 1.10 (0.69-1.75)
 
 III
 91
 21
 73
 23
 1.52 (0.77-3.01)
 
 Lymph-node status
  
  
  
  
  
Vitamin B2, mg
 Negative
 242
 25
 335
 35
 1.28 (0.67-2.42)
 
 Positive
 172
 29
 218
 49
 1.40 (0.81-2.44)
Vitamin B6, mg
 Negative
 251
 28
 326
 32
 1.22 (0.63-2.34)
 
 Positive
 181
 36
 209
 42
 0.88 (0.49-1.56)
Folate, mg
 Negative
 284
 30
 293
 30
 1.23 (0.68-2.24)
 
 Positive
 199
 38
 191
 40
 1.12 (0.67-1.87)
 
 Hormone status
  
  
  
  
  
Vitamin B2, mg
 ER + and/or PR+
 300
 34
 398
 40
 0.91 (0.52-1.59)
 
 ER–/PR–
 111
 21
 153
 43
 2.28 (1.20-4.35)
Vitamin B6, mg
 ER + and/or PR+
 305
 39
 393
 35
 0.57 (0.32-1.03)
 
 ER–/PR–
 125
 26
 139
 38
 1.86 (0.97-3.56)
Folate, mg
 ER + and/or PR+
 333
 39
 365
 35
 0.82 (0.49-1.40)
 
 ER–/PR–
 148
 30
 116
 34
 1.84 (1.02-3.32)
 
 Nuclear grade
  
  
  
  
  
Vitamin B2, mg
 I-II
 223
 23
 302
 34
 1.22 (0.64-2.34)
 
 III
 185
 32
 241
 50
 1.43 (0.82-2.49)
Vitamin B6, mg
 I-II
 226
 29
 299
 28
 0.56 (0.28-1.11)
 
 III
 200
 36
 226
 46
 1.28 (0.73-2.24)
Folate, mg
 I-II
 250
 31
 275
 26
 0.69 (0.38-1.27)
  III 224 38 202 44 1.59 (0.95-2.66)

Abbreviation: ER, estrogen receptor; PR, progesterone receptor.

a Adjusted for age, education, recruited site, TNM stage, hormone status, nuclear grade and total calorie.