Table 4.
Univariate and multivariate Cox regression analyses of different prognostic variables for NPC patients
| Variable | Subset | Hazard ratio (95%) CI | Pvalue |
|---|---|---|---|
| Univariate analysis (n = 507) |
|
|
|
| Hsp70 membranal and cytoplasmic staining |
low vs. high |
0.540 (0.390-0.747) |
<0.001 |
| Hsp70 nucleus staining |
low vs. high |
1.708 (1.241-2.351) |
0.001 |
| Age |
<46 vs. > = 46 |
1.644 (1.202-2.249) |
0.002 |
| Sex |
male vs. female |
0.827 (0.574-1.192) |
0.308 |
| T stage |
T1 + T2 vs. T3 + T4 |
3.149 (2.159-4.594) |
<0.001 |
| N stage |
N0 vs. N1 + N2 + N3 |
2.474 (1.592-3.846) |
<0.001 |
| Recurrence or metastasis |
No vs. Yes |
548.914 (76.728-3.927E3) |
<0.001 |
| Clinical stage |
I + II vs. III + IV |
6.034 (3.352-10.862) |
<0.001 |
| Multivariate analysis (n = 507) |
|
|
|
| Hsp70 cytoplasmic and membranal staining |
low vs. high |
0.529 (0.360-0.778) |
0.001 |
| Hsp70 nuclear staining |
low vs. high |
2.601 (1.785-3.789) |
6.41E-07 |
| Clinical stage | I + II vs. III + IV | 3.641 (1.623-8.170) | 0.002 |
CI, confidence interval; WHO, World Health Organization; Hsp70, heat shock protein 70.