Figure 1. (A) Genomic organization. The EMCV genome is a positive single-strand RNA, covalently linked to the viral protein VPg in 5′. The genomic RNA is composed of two UTR in 5′ and 3′ and an ORF that encodes for a polyprotein (dark gray). The polyproteins is cleaved by the 3C protease, cleavage sites are indicated (black triangles). Ribosome skinping (curved right arrow). A second ORF (clear gray) due to a +2 ribosome frameshifting. cre, Cis replicating element; PKs, pseudoknots; IRES, internal ribosome entry site. (B) Description of EMCV proteins properties and functions known or assumed by similarity with other picornaviruses.