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. 2012 Oct 22;7(10):e47696. doi: 10.1371/journal.pone.0047696

Figure 4. Induction of UGT activity by epirubicin.

Figure 4

Glucuronidation activity was examined by the UGT-Glo Assay using 50 µg of homogenate per reaction in three melanoma cell lines; (A) WM3211 (B) SKmel28 and (C) A375 without treatment and compared to treatment with epirubicin (EPI) at the indicated concentrations for 24 hrs. (−) indicates a negative control in which no homogenate was present. (+) indicates use of human liver microsomes (known to have high concentrations of almost all UGT family members) as a positive control.