Table 3. Fractional Allelic Loss (FAL) describing the number of loss events over the total number of informative events for a sample per cohort.

Feature	N	BRAF mut/MSS Av Fractional Allelic Loss	P Value	N	BRAF wt/MSS Av Fractional Allelic Loss	P Value	P Value between cohorts
Overall	56	0.304	–	90	0.386	–	0.1
AJCC Stage I+ II	13	0.132	0.01	37	0.396	0.82	0.005
AJCC St. III + IV	16	0.362		33	0.412		0.55
AJCC Stage I	2	0.100	0.03	11	0.347	0.92	0.36
AJCC Stage II	11	0.138		26	0.417		0.006
AJCC Stage III	10	0.283		20	0.415		0.28
AJCC Stage IV	6	0.492		13	0.407		0.44
Proximal Loc.	30	0.333	0.91	25	0.325	0.19	0.92
Distal Location	15	0.323		57	0.416		0.25
Female Gender	28	0.225	0.04	39	0.392	0.86	0.02
Male Gender	28	0.383		51	0.381		0.98
P53 Mutant *	20	0.375	0.17	42	0.491	<0.001	0.14
P53 Wild Type *	36	0.260		48	0.274		0.83
CIMP High	24	0.240	0.35	3	0.444	0.81	0.26
CIMP Low/Nil	20	0.321		76	0.404		0.29
Kras Mutant	–	–	–	41	0.320	0.045	–
Kras Wild Type	–	–		49	0.441

^*Average FAL and corresponding p53 mutational status was analysed using CIN data at the 5q, 8p and 18q loci only.