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. 2012 Oct 22;7(10):e45606. doi: 10.1371/journal.pone.0045606

Figure 2. IL-6 and promoter methylation modulate expression of miR-370. A. IL-6 reduces miR-370 expression in HuCCT1 cells.

Figure 2

X-axis – duration of IL-6 treatment (in hours). Y-axis – Mean and standard deviation of qRT-PCR-measured expression of miR-370 normalized to RNU6B. B. Treatment with the demethylating agent 5Aza-dC upregulates miR-370 expression in HuCCT1 cells. Black column - 5Aza-dC-treated cells, gray column – negative control. X-axis –the duration of 5 Aza-dC treatment (hours). Y-axis – Mean and standard deviation of qRT-PCR-measured expression of miR-370 normalized to RNU6B. Data represents the mean value of three independent experiments, **P<0.01, ***P<0.001.