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. 2012 Oct 1;11(19):3536–3542. doi: 10.4161/cc.21462

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Copyright © 2012 Landes Bioscience

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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graphic file with name cc-11-3536-g2.jpg — Figure 2. Both ABT-737 and ABT-263 inhibit the interactions between Bcl-XL/Bcl-2 and Bad or tBid but not BimEL. The binding of (A and D) mCherry-Bad, (B and E) mCherry-tBid and (C and F) mCherry-BimEL to (A-C) Venus-Bcl-XL or (D-F) Venus-Bcl-2 in the presence of vehicle control (DMSO) are shown in black, and the inhibition by ABT-737 and ABT-263 are shown in red and blue respectively. The error bar indicates standard error.