Table 6. States of ER-stress signaling pathways at various nutrient conditions.
| Nutrients | *eIF2α | ATF4 | ATF6 | XBP1 | Cell Fates | |
|---|---|---|---|---|---|---|
|
Gln(-), 24 h |
|
Activation |
Inhibition |
Insignificant |
Inhibition |
Arrest/death |
|
MM01** |
+NH4+ |
Activation |
Activation |
Insignificant |
Insignificant |
Adapted |
| Glc (-), 24 h | Activation | Activation | Activation | Activation | Arrest/death |
*
Based on eIF2α phosphorylation detected in western blots, all other predication was based on IPA analysis.
**
Adapted to Gln-free media, long-term survival and proliferates at slow rate.