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Effects of aldosterone and p21 siRNA on senescence-associated β-galactosidase staining (A-G), and levels of p21 mRNA (H) and protein (I) in human proximal tubular cells at 3 and 5 days after aldosterone treatment. Data are expressed as means ± S.E.M.; n = 6 per group. *P < 0.05, **P < 0.01, compared to the same-day aldosterone-treatment group.
