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Effects of aldosterone and p21 siRNA on tumour necrosis factor (TNF)-α mRNA levels in human proximal tubular cells (A) and protein levels in the culture medium (B) at 3 and 5 days after aldosterone treatment. Data are expressed as means ± S.E.M.; n = 5 or 6 per group. *P < 0.05, **P < 0.01, compared to the same-day aldosterone-treatment group.
