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. Author manuscript; available in PMC: 2013 Oct 28.
Published in final edited form as: J Control Release. 2012 Aug 23;163(2):154–160. doi: 10.1016/j.jconrel.2012.08.019

Figure 1.

Figure 1

Schematic diagram of the setup used showing the coupling solution bath and the mounting cone over which the skin is mounted. For the aluminum foil experiments, the diffusion cell is placed within the rubber cone. It is hypothesized that the high-frequency US horn nucleates small bubbles, which are then pushed below the low-frequency horn by streaming (a). The additional bubbles nucleated by the high-frequency horn grow by rectified diffusion under the influence of the low-frequency horn (b). Once the bubbles reach the threshold size, they collapse against the skin (c).