Table 2.
Densities of AD Lesions, Neurons, Astrocytes, Postsynaptic Spines and Presynaptic Synaptophysin Immunoreactivity in Mid-Frontal Cortex
| Variable | Group Means (SD) | Statistic | Post-Hoc Comparison p-value | ||||
|---|---|---|---|---|---|---|---|
| AD-Resilient (n=10) | AD-Dementia (n=10) | Normal Comparison (n=10) | Kruskal-Wallis Χ2 or ANOVA F, p | AD-Resilient vs. AD-Dem | AD-Resilient vs. Normal | AD-Dementia vs. Normal | |
| Amyloid % Area | 5.1 (2.5) | 5.0 (4.3) | 0.1 (0.3) | Χ2[2]=20.1, p<0.0001 | p=0.54 | p<0.0001 | p<0.0001 |
| Tau NFTs/mm2 | 4.6 (9.8) | 3.5 (6.6) | 0.0 (0.0) | Χ2[2]=14.9, p=0.0006 | p=0.65 | p=0.0002 | p=0.002 |
| NeuN Neurons/mm2 | 445 (125) | 448 (168) | 562 (86) | F[2,27]=2.4, p=0.11 | p=0.97 | p=0.16 | p=0.15 |
| GFAP Astocytes/mm2 | 402 (117) | 276 (114) | 238 (115) | F[2,27]=5.3, p=0.011 | p=0.02 | p=0.005 | p=0.50 |
| Synaptopodin Spines/mm2 | 18997 (11431) | 8904 (10342) | 24426 (9006) | F[2,27]=5.6, p=0.009 | p=0.04 | p=0.26 | p=0.003 |
| Synaptophysin OD* | 1314 (217) | 1091 (276) | 1484 (199) | F[2,27]=6.7, p=0.004 | p=0.04 | p=0.13 | p=0.001 |
*
OD=optical density in gray scale units