Table 3.
Proteins Identified in Antibody Microarray that Differentiated AD-Resilient and AD-Dementia Groups
| Protein UniProt ID | Name (Alphabetical) | Direction of Change in AD- Resilient vs AD-Dementia, p-value | Biological Class and Function |
|---|---|---|---|
| Q02410 | Amyloid beta A4 precursor protein- binding family A member 1 | Increased, 0.0037 | Transporter protein. Interacts and stabilizes amyloid precursor protein (APP), inhbiting production of proteolytic APP fragments including the amyloid-β; signal transduction and possible roles in synaptic vesicle exocytosis and neuronal cell adhesion |
| P30658 | Chromobox protein homolog 2 | Increased, 0.00045 | Adapter protein. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, involved in chromatin remodeling and modification of histones |
| P30281 | Cyclin D3 | Decreased, 0.006 | Cell cycle protein. Regulated CDK Kinases; sensor of astrocyte gap junction communication and possible mitogen mediator of astrocytes |
| P33992 | DNA replication licensing factor MCM5 | Decreased, 0.0091 | Cell cycle protein. Chromatin binding protein, participates in cell cycle regulation |
| P55060 | Exportin-2 | Increased, 0.00019 | Transporter protein. Nuclear-cyoplasmic transport, apoptosis and proliferation |
| P08700 | Interleukin-3 | Increased, 0.0061 | Cell-cell signaling protein. Pleiotropic functions including neuroprotection, inhibition of neuron death induced by Ab, trophic effects in hippocampal neurons, microglial activator. |
| P06239 | Lymphocyte-specific protein tyrosine kinase | Increased, 0.00029 | Protein kinase. Src family tyrosine kinase expressed in neurons, tyrosine phosphorylates tau, down-regulated in AD, Lck gene locus risk for AD |
| Q9UPY8 | Microtubule-associated protein RP/EB family member 3 | Decreased, 0.0062 | Cell cycle protein. Involved in microtubule polymerization stabilization and anchoring; possible role in odor memory |
| P15172 | Myoblast determination protein 1 | Decreased, 0.0047 | Transcription regulator. Myogenic regulatory factor with early role in muscle differentiation |
| Q09013 | Myotonin protein kinase | Increased, 0.00069 | Protein kinase. Serine threonine kinase for myogenin, L-type calcium channels, phophlemman; role in long-term potentiation |
| Q01130 | Serine/arginine-rich splicing factor 2 | Increased, 0.00033 | Splicing factor. Regulates splicing, alternative translation and various RNA metbolism factors; regulates protein sumoylation |
| P67775 | Serine/threonine-protein phosphatase | Decreased, 0.0063 | Protein phosphatase. “PP2A” - Important phosphatase regulating activity of multiple signaling kinases and phosphorylation of proteins including tau |
| P48764 | Sodium/hydrogen exchanger 3 | Increased, 0.0031 | Ion transport. Major proton extruding system component with role in signal transduction |
| P15923 | Transcription factor 3 (E2alpha) | Increased, 1×10-6 | Transpcription rgulator. Regulates neuronal differentiation and survival, binds to sites affecting insulin and k-immunoglobulin genes, enhances expression of HES1 (target of Notch), prevents apoptosis |
| P25445 | Tumor necrosis factor receptor superfamily, member 6 | Decreased, 0.0027 | Apoptosis. Central role in the physiological regulation of programmed cell death via FADD, caspase 8 and caspase 10 |