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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: J Immunol. 2012 Sep 24;189(9):4648–4656. doi: 10.4049/jimmunol.1201806

Figure 5. Composite Cytokine Scores for pro-and anti-inflammatory compartments based on outcome in chronic sepsis.

Figure 5

All cytokine values were normalized (each mediator individually) to the median DIE value of that specific cytokine. The individual activation scores for each tested cytokine were then combined into the pro-inflammatory (i.e. IL-1β, IL-2, IL-5, IL-6, IL-12, IL-17, TNFα, IFNγ, ICAM-1, MIP-1α, MIP-2, MCP-1, Eotaxin, Eotaxin-2) and anti-inflammatory (IL-1ra, IL-4, IL-10, IL-13, TNF srI, TNF srII) panels, and the average response scores were compared based on outcome. DIE (any 6-28 post-CLP day) n=15 SUR (alive by 28 post-CLP day) n=30. Chronic DIE bar represents pooled cytokine values collected within 24h of death. Cytokine values collected from SUR animals were sampled on the same post-CLP day as the DIE mice (see study design). Data presented as mean + SEM. * p < 0.01.