Table 2.

Relative percent expression (mean ± 95% confidence intervals) of (A) interleukin-1β (IL-1β), (B) inflammatory cytokines of interest, and (C) anabolic and (D) catabolic agents in cartilage of viral vector treated knees versus vector control knees (groups 1 and 2) at specified ages.

		Group 1				Group 2
A.	IL-1β
		NTV	TV	P value		Ad-Luc	Ad-hIRAP	P value
	120 days	100.0 (84.1,115.9)	5.5 (3.9,7.1)	< 0.001	120 days	100.0 (90.5,109.5)	ND	< 0.001
	180 days	ND	ND	NA	180 days	ND	ND	NA
B.	TNF-α
		NTV	TV	P value		Ad-Luc	Ad-hIRAP	P value
	120 days	100.0 (80.9,119.1)	15.3 (7.3,23.3)	< 0.001	120 days	100.0 (82.5,117.5)	720.6 (584.1,1357.0)	< 0.001
	180 days	100.0 (87.3,112.7)	23.8 (7.9,39.7)	< 0.001	180 days	100.0 (85.7,114.3)	33.0 (14.7,80.7)	0.01
	IL-8
		NTV	TV	P value		Ad-Luc	Ad-hIRAP	P value
	120 days	100.0 (84.1,115.9)	ND	< 0.001	120 days	100.0 (94.5,105.4)	35.4 (15.5,55.3)	< 0.001
	180 days	100.0 (85.7,114.3)	21.0 (5.1,36.9)	< 0.001	180 days	100.0 (83.7,117.4)	32.2 (17.6, 51.9)	< 0.001
	IFN-γ
		NTV	TV	P value		Ad-Luc	Ad-hIRAP	P value
	120 days	100.0 (94.1,105.9)	120.0 (65.8,239.1)	> 0.05	120 days	100.0 (90.4,109.5)	5 (1.8,8.2)	< 0.001
	180 days	100.0 (86.8,113.4)	75.0 (44.3,194.3)	> 0.05	180 days	100.0 (87.2,113.7)	42.1 (18.2,65.9)	< 0.001
C.	TGF-β1
		NTV	TV	P value		Ad-Luc	Ad-hIRAP	P value
	120 days	100.0 (92.0,108.0)	643.0 (324.8,961.2)	< 0.001	120 days	100.0 (90.5,109.5)	873.2 (236.7,1510.0)	< 0.001
	180 days	100.0 (92.4,108.0)	412.6 (223.9,1049.0)	< 0.001	180 days	100.0 (84.1,115.9)	32.5 (6.8,64.3)	0.008
D.	MMP13
		NTV	TV	P value		Ad-Luc	Ad-hIRAP	P value
	120 days	100.0 (94.1,105.9)	ND	< 0.001	120 days	100.0 (93.4,107.5)	ND	< 0.001
	180 days	100.0 (85.6,114.3)	ND	< 0.001	180 days	100.0 (87.3,112.7)	200.0 (144.3,255.7)	< 0.001

ND = not detected; NA = not applicable.