. 2012 Sep 21;189(9):4520–4527. doi: 10.4049/jimmunol.1201579

Table II. GC formation in BM chimeric mice infected with prions.

Donor BM^a	Host Genotype^b	CD21/35 Expression^c	PrPC Expression^c	% GC⁺^d
WT	WT	Both	Both	72 ± 12
WT	CD21/35^−/−	B cells	Both	22 ± 4^*
CD21/35^−/−	WT	FDCs	Both	78 ± 13
CD21/35^−/−	CD21/35^−/−	Neither	Both	23 ± 3^*
WT	PrP^−/−	Both	B cells	15 ± 11^*
CD21/35^−/−	PrP^−/−	FDCs	B cells	11 ± 7^*
PrP^−/−	WT	Both	FDCs	73 ± 9
PrP^−/−	CD21/35^−/−	B cells	FDCs	21 ± 2^*
PrP^−/−	PrP^−/−	Both	Neither	14 ± 4^*
PrP^−/−CD21/35^−/−	WT	FDCs	FDCs	75 ± 9
PrP^−/−CD21/35^−/−	CD21/35^−/−	Neither	FDCs	19 ± 2^*
PrP^−/−CD21/35^−/−	PrP^−/−	FDCs	Neither	14 ± 5^*
WT	PrP^−/−CD21/35^−/−	B cells	B cells	13 ± 6^*
PrP^−/−	PrP^−/−CD21/35^−/−	B cells	Neither	10 ± 4^*
CD21/35^−/−	PrP^−/−CD21/35^−/−	Neither	B cells	12 ± 2^*
PrP^−/−CD21/35^−/−	PrP^−/−CD21/35^−/−	Neither	Neither	13 ± 4^*

^{^a}

BM was isolated from mice of the indicated genotype.

^{^b}

Hemopoietic systems of sublethally irradiated mice of the indicated genotypes were reconstituted with donor BM.

^{^c}

CD21/35/35 or PrP expression was restricted to the indicated cell types for each reconstitution group.

^{^d}

Mice inoculated with 1% infected brain homogenate analyzed 90 dpi.

p < 0.01.