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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2012 Aug 23;264(3):387–394. doi: 10.1016/j.taap.2012.08.015

Figure 1.

Figure 1

Serum enzymes in mice and rats treated with APAP. Mice and Fischer 344 rats were treated i.p. with 300 mg APAP/kg body weight or 1 g APAP/kg, respectively. At various times, the animals were sacrificed and serum was collected. (A) Time course of ALT activity in serum from mice and rats after APAP. (B) Time course of glutamate dehydrogenase (GDH) activity in serum from mice and rats. (C) Representative H&E stained liver sections from mice (top row) and rats (bottom row) treated with APAP. Data are expressed as mean ± SEM for n = 3–4 animals per group. *P < 0.05 (compared to t=0).