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Nitrotyrosine staining in mice (top row) and rats (bottom row) after APAP treatment. Mice and rats were treated i.p. with 300 mg APAP /kg body weight or 1 g APAP/kg, respectively. At the indicated times, the animals were sacrificed and livers were fixed in phosphate-buffered formalin. Sections were stained using an anti-3-nitrotyrosine antibody.
