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. Author manuscript; available in PMC: 2013 Oct 28.
Published in final edited form as: J Control Release. 2012 Sep 7;163(2):130–135. doi: 10.1016/j.jconrel.2012.08.032

Figure 3.

Figure 3

Radially averaged fluorescence intensity profiles of doxorubicin and/or chi-p53 nanoparticles in representative double-walled PLA(PLGA) microspheres. The inserts are the confocal images captured at the centerline of the microspheres. (a), (d) and (g) are the profiles of doxorubicin (green) for formulation B microspheres with increasing molecular weights of PLA shell layer, i.v. = 0.37, 0.70 and 1.05 dL/g, respectively. (b), (e) and (h) are the profiles of chi-p53 nanoparticles (red) for formulation C microspheres with increasing molecular weights of PLA shell layer, i.v. = 0.37, 0.70 and 1.05 dL/g, respectively. (c), (f) and (i) are the profiles of doxorubicin (green) and chi-p53 nanoparticles (yellow) for formulation D microspheres with increasing molecular weights of PLA shell layer, i.v. = 0.37, 0.70 and 1.05 dL/g, respectively.