FIG. 1.

TLR4 deficiency attenuates weight gain and hepatic TG accumulation after HF feeding. A: WT and TLR4-deficient mice display similar growth curves on a LF diet, whereas weight gain is attenuated in TLR4^−/− mice after HF^MUFA and HF^SFA feeding (n = 13–15 for all diet conditions). B: TLR4 deficiency reduces HF-feeding–induced hepatic TG accumulation (n = 13–16). C: Representative images of ORO-stained liver sections. Data are presented as mean ± SEM. **P < 0.01 and ***P < 0.001 for WT HF^SFA vs. TLR4^−/− HF^SFA; #P < 0.05 for WT HF^MUFA vs. TLR4^−/− HF^MUFA; ‡P < 0.01 for genotype effect; and P < 0.05 for groups not connected by the same letter. (A high-quality digital representation of this figure is available in the online issue.)