Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Oct 16;61(11):2718–2727. doi: 10.2337/db11-1595

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2012 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

PMC Copyright notice

FIG. 4. — TLR4 deficiency does not attenuate systemic IR after HF^SFA feeding. A: Time course of blood glucose throughout the hyperinsulinemic-euglycemic clamp is presented to illustrate clamp quality. B: The glucose infusion rate required to maintain blood glucose between 120 and 130 mg/dL did not differ between HF^SFA-fed TLR4^−/− and WT mice. WT and TLR4^−/− mice displayed similar rates of endogenous glucose production (EndoR_a) (C) and glucose disappearance (R_d) (D). E: Glucose uptake (R_g) was significantly reduced in the gastrocnemius (Gastroc), superficial vastus lateralis (SVL), and AT of TLR4^−/− mice compared with WT. Data are presented as mean ± SEM (n = 4–7). **P < 0.01 and ***P < 0.0001 for TLR4^−/− compared with WT.