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. 2012 Oct 16;61(11):2893–2905. doi: 10.2337/db12-0006

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© 2012 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 8. — B cells and activation of self-reactive CD4⁺ T cells. A: Representative dot plots showing frequency of Vβ4⁺CD44^hiCD4⁺ T cells in spleen (SPLN) and PLN of 16-week old NOD mice (n = 6), NOD.µMT mice (n ≥ 3), and NOD.µMT mixed bone marrow–B-cell chimeras reconstituted with NOD B cells (n = 6) or with NOD.β₂m^−/− B cells (n = 3). Percentage given indicates median value. B: Cumulative data, mean ± SEM, calculated from A. C: Representative dot plots showing frequency of IL-21⁺CD44^hiCD4⁺ T cells in the spleen (SPLN) and PLN of 16-week-old NOD mice (n = 6), NOD.µMT mice (n = 3), and NOD.µMT mixed bone marrow–B-cell chimeras reconstituted with NOD B cells (n = 6) or with NOD.β₂m^−/− B cells (n = 3). Percentage given indicates median value. IL-21^−/− mice were used to control for specificity. D: Cumulative data, mean ± SEM, calculated from C.