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. 2012 Oct 16;61(11):2734–2742. doi: 10.2337/db11-1621

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© 2012 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 3. — FM clamping improves glucose tolerance and insulin sensitivity. Glucose tolerance was assessed at week 13 via intraperitoneal GTT. After 6 h of fasting mice were injected with 2.0 g/kg glucose. FMC mice had significantly lower blood glucose excursion (A) and area under the curve (AUC; C) compared with lean SD and obese HFD mice. Insulin tolerance was assessed at week 13 via intraperitoneal insulin challenge (1 unit/kg). Insulin tolerance was significantly improved in FMC mice as compared with HFD mice when assessed by either blood glucose excursion (B) or rate of disappearance (K_d) over the initial 30 min (D). All data are represented as mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001.