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. 2012 Oct 16;61(11):2734–2742. doi: 10.2337/db11-1621

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© 2012 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 7. — CR induces persistent hyperphagia. A: At day 45 CR was ended and mice of all groups were fasted for 24 h. After the fast mice were given free access to SD or HFD and food intake was measured after 15 h. B: After the fasting-induced hyperphagia experiment mice were allowed to eat ad libitum to study rebound of obesity. Additional control groups (FMC-SD and previously SD-fed ad libitum and switched to HFD ad libitum [SD-HFD]) were introduced. FMC-SD mice were previously fed HFD and were switched to SD, whereas SD-HFD mice were previously fed SD and were switched to HFD. C: BW curves of the ad libitum eating period. D: FM during the period of ad libitum eating. All mice are male (n = 7 to 8 per group). All data are represented as mean ± SEM. Lowercase letters denote statistically similar (P > 0.05) groups.