FIG. 3.

Observed proteinuria in DM+VEGFKO mice. A: A Kaplan-Meier curve shows a number of mice remaining without significant proteinuria (defined as protein-to-creatinine ratio >20 mg/mg or 4+ on dipstick). Significant proteinuria began earlier and was observed in a much larger proportion of DM+VEGFKO mice by the end of study (60%) compared with all other groups. B: Protein-to-creatinine ratio of mice dissected at 7–8 weeks post-STZ showed a significantly higher degree of proteinuria in DM+VEGFKO mice compared with all other groups. *P < 0.05, **P < 0.01.