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Dynamic changes of miR-146a direct targets IRAK1 and TRAF6 during the wound-healing process. A: IRAK1 and TRAF6 mRNA structure and predicted targets of miR-146a by the TargetScan Web site (http://www.targetscan.org/). Real-time quantitative RT-PCR analysis of mRNA for IRAK1 (B) and TRAF6 (C) in db/+ (Hz; n = 5) and db/db (n = 5) wounds at 1, 3, 7, 14, and 21 days after dermal injury. #P < 0.01 comparing db/db wounds with db/+ wounds.
