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MSC treatment downregulates levels of NF-κB, IL-6, and MIP-2 in diabetic wounds. Real-time quantitative RT-PCR analysis of mRNA, IRAK1 (A), TRAF6 (B), NF-κB (C), IL-6 (D), and MIP-2 (E) in db/+ (Hz; n = 5) and db/db (n = 5) wounds at days (D) 3 and 7 after dermal injury with MSCs or vehicle treatment. F: ELISA analysis of wound MIP-2 protein concentration.
