FIG. 3.

Acute central injection of GLP-1R and GCGR agonists increases electrophysiological activity of the sympathetic fibers that innervate the iBAT. Activity of sympathetic nerves projecting to iBAT increased after acute ICV administration of GCG (A), OXM (B), or GLP-1 (C). Repeated-measures ANOVA shows a significant main effect for all compounds at all doses; P < 0.01. D–F: Histograms on the right show average % increase for final hour, which was significant for all compounds as determined by one-way ANOVA with Tukey post hoc (D and E) and Student t test (F) (*P < 0.05, **P < 0.01). Data are expressed as means ± SE (n = 6–8). VH, vehicle.