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. 2012 Sep 24;109(41):E2757-E2765. doi: 10.1073/pnas.1205788109

Fig. 1.

Fig. 1.

The Notch receptor and the NRR of hN2. (A) The domain structure of the Notch receptor contains an extracellular region, consisting of the NRR and the EGF-like repeats (green; repeats required for ligand interactions are striped). The NRR comprises three LNR modules (light pink to dark pink) and the furin-cleaved HD domain (HD-N, dark blue; HD-C, light blue). Approximate positions of S2 and S3 cleavage sites, which release the intracellular domain, are shown. (B) X-ray crystal structure of hN2-NRR in its autoinhibited conformation. The LNR and HD domains are colored as in A, each LNR containing a coordinated calcium ion (green) and three disulfide bonds (red lines). The zinc ion, coordinated by residues of the B∶C linker and HD domain, is shown in gray. The S2 cleavage site is highlighted by a black arrow. The furin cleavage loop (S1) is indicated by a red arrow. PDB ID code 2OO4 (12). Figure created using PyMol (version 1.3).