Table 3.

Effect of lonafarnib on carotid artery density by ultrasound

		Median density in pixels (range)			P value
Site	Percentile	Control (n = 55)	HG(P) (n = 22)	HG(E) (n = 22)	Control vs. HG(P)*	HG(P) vs. HG(E)†	Control vs. HG(E)*
Intima media	50	73.0 (28.0–156.0)	87.0 (15.0–242.0)	72.0 (2.0–140.0)	0.002	0.002	0.75
Adventitia luminal near wall	50	169.0 (95.0–237.0)	228.0 (61.0–254.0)	170.0 (70.0–252.0)	0.0004	0.003	0.46
Adventitia deep near wall	50	166.0 (34–254.0)	167.0 (30.0–254.0)	121.0 (12.0–215.0)	0.32	0.05	0.002

HG(E), HGPS end of therapy; HG(P), HGPS pretherapy.

*Based on Wilcoxon rank-sum test.

^†Wilcoxon signed-rank test based on distributions of fold-change (post-/pre-treatment) calculated for each patient.