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. 2012 Sep 24;109(41):16690–16695. doi: 10.1073/pnas.1207832109

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Fig. 4. — BdlA-Y238 phosphorylation and elevated c-di-GMP levels are required for BdlA cleavage. (A) Detection of the wild-type and Y238A C-terminally V5/His-tagged variants of BdlA in planktonic and biofilm PAO1 cells reveals that Y238 is required for BdlA cleavage. (B and C) Expression of wild-type (∆bdlA/p_bdlA-bdlA), but not of the Y238A variant (∆bdlA/p_bdlA-bdlA-Y238A), restores dispersion of ∆bdlA biofilms to wild-type levels. (D) Overexpression of cyclase PA4843 correlates with BdlA cleavage under planktonic growth conditions and dipA overexpression impairs BdlA processing under biofilm growth conditions.