Table 2.
Animal Models: Gestational Exposure to Maternal Antibodies and Offspring Behavior
Mouse Models | The serum from a mother of children with ASD was injected into mice during gestation. The resulting offspring had altered exploration and motor coordination with changes in cerebellar magnetic resonance spectroscopy. | (Dalton, 2003 #5) |
The transplacental passage of IgG antibodies, collected from mothers of children with autism, is capable of inducing long-term behavioral changes in the resulting offspring. | (Singer, 2009 #19) | |
Monkey Models | Pregnant rhesus monkeys were exposed maternal antibodies, collected from mothers of children with autism, during gestation and their offspring demonstrated significantly more stereotypies and higher levels of motor activity than control monkeys | (Martin, 2008 #15) |