Table 1.
Major Coexisting Conditions at Baseline and during the Study, According to Treatment Group.*
| Condition | Overall (N = 699) | Metformin Alone (N = 232) | Metformin plus Rosiglitazone (N = 233) | Metformin plus Lifestyle Intervention (N = 234) |
|---|---|---|---|---|
| number of participants (percent) | ||||
| Hypertension | ||||
| Cases at baseline | 81 (11.6) | 28 (12.1) | 27 (11.6) | 26 (11.1) |
| New cases during study | 155 (22.2) | 57 (24.6) | 53 (22.7) | 45 (19.2) |
| Dyslipidemia | ||||
| Elevated LDL cholesterol | ||||
| Cases at baseline | 23 (3.3) | 9 (3.9) | 8 (3.4) | 6 (2.6) |
| New cases during study | 49 (7.0) | 18 (7.8) | 16 (6.9) | 15 (6.4) |
| Triglyceridemia | ||||
| Cases at baseline | 127 (18.2) | 51 (22.0) | 38 (16.3) | 38 (16.2) |
| New cases during study | 70 (10.0) | 20 (8.6) | 28 (12.0) | 22 (9.4) |
| Microalbuminuria | ||||
| Cases at baseline | 44 (6.3) | 21 (9.1) | 8 (3.4) | 15 (6.4) |
| New cases during study | 72 (10.3) | 25 (10.8) | 27 (11.6) | 20 (8.5) |
Diagnosis of a coexisting condition was made on the basis of an out-of-range value repeated within 6 months or the use of appropriate medication in lieu of a laboratory value. Cutoff values for hypertension were a blood-pressure level at or above the 95th percentile, systolic pressure of 130 mm Hg or more, or diastolic pressure of 80 mm Hg or more; for dyslipidemia, a low-density lipoprotein (LDL) cholesterol level of 130 mg per deciliter (3.4 mmol per liter) or more or a triglyceride level of 150 mg per deciliter (1.7 mmol per liter) or more; and for microalbuminuria, a urinary albumin:creatinine ratio of 30 or more, with albumin measured in milligrams per deciliter and creatinine in grams per deciliter.