Fig. 1.

wapl transcripts, mutations and proteins. (A) Top black line is wapl DNA. Large and small wapl transcripts are produced from independent transcription start sites (arrows). The two transcripts encoding Wapl-L and Wapl-S are shown. Exons are thick lines (gray, non-coding; black, coding). Introns are dotted lines. Locations of the wapl² and wapl^AG mutations are shown. Sequencing of wapl² mutants identified an insertion of 970 bases from the Egf gene normally found on chromosome 2R. The wapl^AG mutation consists of a single nucleotide change of C to T at position 1583 of the cDNA sequence. The antigens used to generate the two antibodies and the predicted sizes of the three Wapl proteins discussed in this paper are also shown.