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. 2012 Nov 15;139(22):4239–4249. doi: 10.1242/dev.080671

Fig. 2.

Fig. 2.

Lef1 is not required for Wnt signaling in mouse mammary mesenchyme. (A,E) X-gal staining of Lef1−/−;TOPGAL-C embryos demonstrating normal Wnt signaling in the mammary mesenchyme in buds 4 and 5 at E15.5. (B,F) Loss of Lef1 does not alter the ectopic Wnt signaling that is induced by PTHrP-overexpression. (C,G) Ectopic Wnt signaling induced by epidermal overexpression of PTHrP in K14-PTHrP mice at E15.5; for comparison with B and F. (D,H) Ectopic Wnt reporter activity is not observed in the ventral skin of TOPGAL-C embryos. Dotted lines delineate the dermo-epidermal junction and the mammary bud. Scale bars: 100 μm.