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. 2012 Nov 15;139(22):4261–4270. doi: 10.1242/dev.082255

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Fig. 3. — Delta/Notch pathway elements at the roof plate boundary. In situ hybridisation at the hindbrain/roof plate interface in transverse section at E5 (B-F are serial sections through the same brain) and at E4 (A,G,H). (A) gdf7 (blue) is expressed in roof plate cells at the boundary with the atoh1-positive (red) rhombic lip (arrow). (B) cdelta1 is expressed in neuroepithelial ventricular zone and excluded from the gdf7-positive domain. (C) cserrate1 is expressed strongly in the rhombic lip. (D) lfng is expressed uniformly and exclusively in neuroepithelial precursors. (E) cnotch1 is expressed in the ventricular zone throughout the hindbrain neuroepithelial ventricular zone and at a low level within the gdf7 domain. (F) cnotch2 is highly expressed in the gdf7-positive domain and uniformly at low levels within the roof plate epithelium and neuroepithelial ventricular zone. (G,H) The Hes1 homologues (G) chairy1 and (H) chairy2 are expressed in a complex regional pattern within the neuroepithelium, and are both highly expressed at the roof plate boundary. Scale bar: 100 μm.